Glial Progenitors in the CNS and Possible Lineage Relationships Among Them
نویسندگان
چکیده
منابع مشابه
NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration
The mammalian CNS contains a ubiquitous population of glial progenitors known as NG2+ cells that have the ability to develop into oligodendrocytes and undergo dramatic changes in response to injury and demyelination. Although it has been reported that NG2+ cells are multipotent, their fate in health and disease remains controversial. Here, we generated PDGFαR-CreER transgenic mice and followed ...
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15 صفحه اولTransplanting oligodendrocyte progenitors into the adult CNS.
This review covers a number of aspects of the behaviour of oligodendrocyte progenitors following transplantation into the adult CNS. First, an account is given of the ability of transplanted oligodendrocyte progenitors, grown in tissue culture in the presence of PDGF and bFGF, to extensively remyelinate focal areas of persistent demyelination. Secondly, we describe how transplanted clonal cell ...
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ژورنال
عنوان ژورنال: Biology of the Cell
سال: 2004
ISSN: 0248-4900
DOI: 10.1111/j.1768-322x.2004.tb01416.x